Chen Institute Homepage
/
People
/
Sarkis Mazmanian
Sarkis Mazmanian
Luis B. and Nelly Soux Professor of Microbiology; Merkin Institute Professor
Immunologic and neurologic imbalances underlie many diseases. The human body represents a scaffold upon which multitudes of commensal species build residence, creating a diverse ecosystem with members of five of the six kingdoms of life. Mechanisms that mediate the interdependent and complex interactions between the microbiome and animals, as well as their influences on human health, represent an exciting frontier of science and medicine. The Mazmanian lab aims to discover how gut bacteria influence the development and function of the immune and nervous systems, with the goal of understanding mechanisms by which the microbiome contributes to the critical balance between health and disease.
Publications
- Griffiths, Jessica A.;Yoo, Bryan B. et al. (2024) Peripheral neuronal activation shapes the microbiome and alters gut physiologyCell Reports
- Nemet, Ina;Funabashi, Masanori et al. (2023) Microbe-derived uremic solutes enhance thrombosis potential in the hostmBio
- Morton, James T.;Jin, Dong-Min et al. (2023) Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profilesNature Neuroscience
- Boktor, Joseph C.;Sharon, Gil et al. (2023) Integrated Multi‐Cohort Analysis of the Parkinson's Disease Gut MetagenomeMovement Disorders
- Ousey, James;Boktor, Joseph C. et al. (2023) Gut microbiota suppress feeding induced by palatable foodsCurrent Biology
- Boktor, Joseph C.;Adame, Mark D. et al. (2022) Global metabolic profiles in a non-human primate model of maternal immune activation: implications for neurodevelopmental disordersMolecular Psychiatry
- Abdel-Haq, Reem;Schlachetzki, Johannes C. M. et al. (2022) A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing miceeLife
- Boktor, Joseph C.;Sharon, Gil et al. (2022) Integrated multi-cohort analysis of the Parkinson's disease gut metagenome
- Chen, Xinhong;Ravindra Kumar, Sripriya et al. (2022) Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systemsNeuron
- Abdel-Haq, Reem;Schlachetzki, Johannes C. M. et al. (2022) A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice