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Paul W. Sternberg
Paul W. Sternberg
Bren Professor of Biology; William K. Bowes Jr. Leadership Chair, Division of Biology and Biological Engineering
Sternberg's lab seeks to understand how the properties of an organism – its development, physiology and behavior – are encoded in its genome. They primarily use molecular genetics of the nematode Caenorhabditis elegans but also apply proteomics, computational biology, biochemistry, cell biology, imaging, behavioral analysis, optogenetics, synthetic biology to not only C. elegans but also parasitic nematodes, budding yeast, mice, jellyfish, fungi, and human cells as needed.
Specific areas of current interest are:
- How does the 302-neuron worm brain assess the future environment based on computation of sensory and physiological inputs?
- Does the male worm have a neural representation of its mating partner?
- How can we best predict gene expression from DNA sequence?
- What are the functional consequences of de novo genetic variants found in individual with autism spectrum disorder?
- What changes in the nervous system occur during sleep?
- How do cells migrate accurately during development?
Publications
- Zhang, Mark G.;Seyedolmohadesin, Maedeh et al. (2024) Sensory integration of food and population density during the diapause exit decision involves insulin-like signaling in Caenorhabditis elegansProceedings of the National Academy of Sciences
- Tan, Chieh-Hsiang;Wang, Ting-Yu et al. (2024) Single-tissue proteomics in Caenorhabditis elegans reveals proteins resident in intestinal lysosome-related organellesProceedings of the National Academy of Sciences
- Prakash, Sharan J.;Van Auken, Kimberly M. et al. (2024) Correction: Semantic representation of neural circuit knowledge in Caenorhabditis elegansBrain Informatics
- Aleksander, Suzanne A.;Anagnostopoulos, Anna V. et al. (2024) Updates to the Alliance of Genome Resources central infrastructureGenetics
- Wright, Adam;Wilkinson, Mark D. et al. (2024) FAIR Header Reference genome: a TRUSTworthy standardBriefings in Bioinformatics
- Sternberg, Paul W.;Van Auken, Kimberly et al. (2024) WormBase 2024: status and transitioning to Alliance infrastructureGenetics
- Ross, Karen E.;Bastian, Frederic B. et al. (2024) Perspectives on tracking data reuse across biodata resourcesBioinformatics Advances
- Markarian, Nicholas;Van Auken, Kimberly M. et al. (2024) Enrichment on steps, not genes, improves inference of differentially expressed pathwaysPLOS Computational Biology
- Schwartz, Hillel T.;Tan, Chieh-Hsiang et al. (2024) Molecular identification of a peroxidase gene controlling body size in the entomopathogenic nematode Steinernema hermaphroditumGenetics
- Banerjee, Navonil;Rojas Palato, Elisa J. et al. (2024) Distinct neurogenetic mechanisms establish the same chemosensory valence state at different life stages in Caenorhabditis elegansG3: Genes, Genomes, Genetics