Chen Institute Homepage
/
People
/
Mary B. Kennedy
Mary B. Kennedy
The Allen and Lenabelle Davis Professor of Biology
Researchers in Mary Kennedy's group focus on understanding what takes place at the molecular level in the brain when neuronal synapses are altered to store information during learning. A co-leader of Caltech's Center for Data-Driven Discovery, Kennedy applies new methods and tools being developed by the center to create computer simulations that can help us understand how synapses are regulated by enzymes during learning. She aims to gain and share the capability to simulate molecular mechanisms in detail and then use experiments to test predictions of the simulations.
Publications
- Bartol, Thomas M.;Ordyan, Mariam et al. (2024) A spatial model of autophosphorylation of Ca²⁺/calmodulin-dependent protein kinase II in a glutamatergic spine reveals dynamics of kinase activation in the first several seconds after a complex synaptic stimulus
- Husar, Adam;Ordyan, Mariam et al. (2024) MCell4 with BioNetGen: A Monte Carlo simulator of rule-based reaction-diffusion systems with Python interfacePLoS Computational Biology
- Chongtham, Anjalika;Isas, J. Mario et al. (2021) Amplification of neurotoxic HTTex1 assemblies in human neuronsNeurobiology of Disease
- Chongtham, Anjalika;Isas, J. Mario et al. (2021) Sonicated fibrils of huntingtin exon-1 preferentially seed neurons and produce toxic assemblies
- Ordyan, Mariam;Bartol, Tom et al. (2020) Interactions between calmodulin and neurogranin govern the dynamics of CaMKII as a leaky integratorPLoS Computational Biology
- Mastro, Tara L.;Preza, Anthony et al. (2020) A sex difference in the response of the rodent postsynaptic density to synGAP haploinsufficiencyeLife
- Pharris, Matthew C.;Patel, Neal M. et al. (2019) A multi-state model of the CaMKII dodecamer suggests a role for calmodulin in maintenance of autophosphorylationPLoS Computational Biology
- Mastro, Tara L.;Preza, Anthony et al. (2019) A sex difference in the composition of the rodent postsynaptic density
- Bear, Mark F.;Cooke, Sam F. et al. (2018) In memoriam: John Lisman – commentaries on CaMKII as a memory moleculeMolecular Brain
- Walkup, Ward G., IV;Sweredoski, Michael J. et al. (2018) Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPasesBiochemical and Biophysical Research Communications