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Long Cai
Long Cai
Professor of Biology and Biological Engineering
The Cai lab pioneered the field of spatial genomics. They developed tools such as seqFISH that allows >10,000 genes to be detected in situ with single molecule resolution in tissues. They also developed MEMOIR to record molecular events into the genome of cells in collaboration with Michael Elowitz's lab. These transformative tools have allowed them to discover unexpected dynamics in stem cell biology, uncover spatial organization in the brain and embryos. They continue to explore questions in developmental biology and neuroscience, as well as generating spatial atlas of organisms at the single cell resolution.
Publications
- Polonsky, Michal;Gerhardt, Louisa M. S. et al. (2024) Spatial transcriptomics defines injury specific microenvironments and cellular interactions in kidney regeneration and diseaseNature Communications
- Jain, Sanjay;Pei, Liming et al. (2024) Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)Nature Cell Biology
- Polonsky, Michal;Gerhardt, Louisa M. S. et al. (2023) Spatial transcriptomics defines injury-specific microenvironments in the adult mouse kidney and novel cellular interactions in regeneration and diseasebioRxiv
- Lohoff, T.;Ghazanfar, S. et al. (2022) Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesisNature Biotechnology
- Cable, Jennifer;Elowitz, Michael B. et al. (2021) Single cell biology—a Keystone Symposia reportAnnals of the New York Academy of Sciences
- Takei, Yodai;Zheng, Shiwei et al. (2021) Single-cell nuclear architecture across cell types in the mouse brainScience
- Dar, Daniel;Dar, Nina et al. (2021) Spatial transcriptomics of planktonic and sessile bacterial populations at single-cell resolutionScience
- Takei, Yodai;Zheng, Shiwei et al. (2021) Integrated spatial genomics in tissues reveals invariant and cell type dependent nuclear architecture
- Jang, Min Jee;Coughlin, Gerard M. et al. (2021) Deep Tropism Profiling of Barcoded AAV Capsid and Cargo Pools in Intact Tissue Using High-Throughput Ultrasensitive Sequential FISHMolecular Therapy
- Chow, Ke-Huan K.;Budde, Mark W. et al. (2021) Imaging cell lineage with a synthetic digital recording systemScience