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Linda Hsieh-Wilson
Linda Hsieh-Wilson
Milton and Rosalind Chang Professor of Chemistry; Merkin Institute Professor
Research in Linda Hsieh-Wilson's group combines organic chemistry and neurobiology to probe the molecular basis of fundamental brain processes. Hsieh-Wilson and her students investigate the molecular mechanisms that allow neuronal communication. The group explores chemical changes at a cell's synapse as well as changes in intracellular proteins when nerve cells are stimulated. By understanding these processes, they hope to elucidate the chemical changes that are relevant for learning and memory, and better inform efforts to develop strategies for intervention when these processes break down.
Publications
- Zhu, Qiang;Chaubard, Jean-Luc et al. (2024) Chemoenzymatic Labeling, Detection and Profiling of Core Fucosylation in Live CellsJournal of the American Chemical Society
- Ramadan, Sherif;Mayieka, Morgan et al. (2024) Recent advances in the synthesis of extensive libraries of heparan sulfate oligosaccharides for structure–activity relationship studiesCurrent Opinion in Chemical Biology
- Wang, Lei;Sorum, Alexander W. et al. (2023) Efficient platform for synthesizing comprehensive heparan sulfate oligosaccharide libraries for decoding glycosaminoglycan–protein interactionsNature Chemistry
- Sorum, Alexander W.;Hsieh-Wilson, Linda C. (2023) Synthesis of oligosaccharide libraries for systematic explorations of heparan sulfate sequence spaceNature Chemistry
- Wang, Lei;Sorum, Alexander W. et al. (2023) Efficient platform for synthesizing comprehensive heparan sulfate oligosaccharide libraries for decoding glycosaminoglycan-protein interactionsNature Chemistry
- Griffin, Matthew E.;Thompson, John W. et al. (2023) Functional glycoproteomics by integrated network assembly and partitioning
- Huang, Huiqian;Joffrin, Amélie M. et al. (2023) Chondroitin 4-O-sulfation regulates hippocampal perineuronal nets and social memoryProceedings of the National Academy of Sciences of the United States of America
- Baryal, Kedar N.;Ramadan, Sherif et al. (2023) Synthesis of a Systematic 64-Membered Heparan Sulfate Tetrasaccharide LibraryAngewandte Chemie International Edition
- Zhang, Jicheng;Liang, Li et al. (2022) Expedient Synthesis of a Library of Heparan Sulfate‐Like "Head-to-Tail" Linked Multimers for Structure and Activity Relationship StudiesAngewandte Chemie International Edition
- Wang, Lei;Huang, Bo-Shun et al. (2022) Automated Platform for the Synthesis of Heparan Sulfate Oligosaccharide Libraries for Decoding Glycosaminoglycan-Protein Interactions