Sleep is among the most enduring mysteries in biology. Although we devote a third of our lives to sleep, sleep disorders are pervasive in modern societies, and sleep-like states are evolutionarily conserved, mechanisms that underlie this behavioral state remain poorly understood. The Prober lab is taking a new approach to this old problem by using zebrafish to identify genetic and neuronal mechanisms that regulate sleep and wakefulness.
Publications
- Chen, Alex B.;Duque, Marc et al. (2024) Norepinephrine changes behavioral state via astroglial purinergic signaling
- Barlow, Ida L.;Mackay, Eirinn et al. (2023) The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulationeLife
- Pollak, Daniel J.;Chawla, Gautam et al. (2023) First steps into the cloud: Using Amazon data storage and computing with Python notebooksPLoS ONE
- Wagle, Mahendra;Zarei, Mahdi et al. (2022) Brain-wide perception of the emotional valence of light is regulated by distinct hypothalamic neuronsMolecular Psychiatry
- Tran, Steven;Prober, David A. (2022) Validation of Candidate Sleep Disorder Risk Genes Using ZebrafishFrontiers in Molecular Neuroscience
- Lee, Daniel A.;Oikonomou, Grigorios et al. (2022) Large-scale Analysis of Sleep in ZebrafishBio-protocol
- Andreev, Andrey;Vasnarungruengkul, Pavee et al. (2021) Open-Source Thermometer, Temperature Controller, and Light Meter for Use in Animal Facilities and During Experiments
- So, Juhoon;Kim, Minwook et al. (2021) Attenuating the Epidermal Growth Factor Receptor–Extracellular Signal‐Regulated Kinase–Sex‐Determining Region Y‐Box 9 Axis Promotes Liver Progenitor Cell‐Mediated Liver Regeneration in ZebrafishHepatology
- Lee, Daniel A.;Oikonomou, Grigorios et al. (2020) Neuropeptide VF neurons promote sleep via the serotonergic rapheeLife
- Barlow, Ida L.;Mackay, Eirinn et al. (2020) A genetic screen identifies dreammist as a regulator of sleep