Changhuei Yang
Professor Yang's research area is biophotonics—the imaging and extraction of information from biological targets through the use of light. His research efforts can be categorized into two major groups – Chip-scale microscopy imaging and Time-reversal based optical imaging.
Chip-scale microscopy - Prof. Yang's group is developing a number of technologies aimed at transforming the conventional microscope into chip-scale, automated and cost-effective formats. His group is the pioneer of the first chip-scale microscope system - the optofluidic microscope. The self-imaging petri dish, ePetri, is the group's most recent major innovation in this research area.
Time-reversal based optical imaging - Prof. Yang's group is working on the use of 'time-reversal' techniques to undo the effect of tissue light scattering. This work has the potential to enable greatly improved depth-penetration and resolution improvement for deep tissue optical imaging. It also opens up the possibility for performing incision-less laser surgery and precision cancer therapy.
Prof. Yang joined Caltech in 2003. He is an Electrical Engineering and Bioengineering professor. He has received the NSF Career Award, the Coulter Foundation Early Career Phase I and II Awards, and the NIH Director's New Innovator Award. Discover Magazine included Prof. Yang as one of the top 20 scientists under 40 in their list of Best Brains in Science 2008.
Publications
- Huang, Yu Xi;Mahler, Simon et al. (2024) Correlating stroke risk with non-invasive cerebrovascular perfusion dynamics using a portable speckle contrast optical spectroscopy laser deviceBiomedical Optics Express
- Zhao, Shi;Zhou, Haowen et al. (2024) Efficient, gigapixel-scale, aberration-free whole slide scanner using angular ptychographic imaging with closed-form solutionBiomedical Optics Express
- Zhou, Haowen;Lin, Siyu et al. (2024) Length-scale study in deep learning prediction for non-small cell lung cancer brain metastasisScientific Reports
- Zhang, Oumeng;Alcalde, Reinaldo E. et al. (2024) Investigating 3D microbial community dynamics of the rhizosphere using quantitative phase and fluorescence microscopyProceedings of the National Academy of Sciences
- Dong, Zhenyu;Mahler, Simon et al. (2024) Non-invasive laser speckle contrast imaging (LSCI) of extra-embryonic blood vessels in intact avian eggs at early developmental stagesBiomedical Optics Express
- Yin, Siyuan;Cao, Ruizhi et al. (2024) Can deep neural networks work with amplitude and phase input of defocused images?Optics Express
- Zhang, Oumeng;Dahlquist, Nic et al. (2024) Long-term imaging of three-dimensional hyphal development using the ePetri dishBiomedical Optics Express
- Cao, Ruizhi;Shen, Cheng et al. (2024) High-resolution, large field-of-view label-free imaging via aberration-corrected, closed-form complex field reconstructionNature Communications
- Zhou, Haowen;Watson, Mark et al. (2024) AI‐guided histopathology predicts brain metastasis in lung cancer patientsJournal of Pathology
- Huang, Yu Xi;Mahler, Simon et al. (2024) A compact and cost-effective laser-powered speckle visibility spectroscopy (SVS) device for measuring cerebral blood flow