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Alexander J. Varshavsky
Alexander J. Varshavsky
Thomas Hunt Morgan Professor of Biology
The Varshavsky lab is focused on the ubiquitin system and related fields. During the 1980's, Varshavsky and colleagues produced the first evidence that ubiquitin is required for protein degradation in living cells. They also discovered the first degradation signals of the ubiquitin system, its first physiological functions, and its crucial mechanistic attributes such as the multi-ubiquitin chain and subunit selectivity of proteolysis. Their current work continues this line of studies. In addition, they are investigating the molecular-level cause of sleep.
Publications
- Varshavsky, Alexander (2024) N-degron pathwaysProceedings of the National Academy of Sciences
- Varshavsky, Alexander;Lewis, Kim et al. (2023) Deletions of DNA in cancer and their possible uses for therapyBioessays
- Varshavsky, Alexander;Finley, Daniel et al. (2023) Dieter Wolf (1941–2023): a life dedicated to understanding protein quality control and the ubiquitin‐proteasome systemEMBO Journal
- Kim, Bong Heon;Kim, Min Kyung et al. (2022) Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substratesProceedings of the National Academy of Sciences of the United States of America
- Chen, Shun-Jia;Kim, Leehyeon et al. (2021) Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathwayProceedings of the National Academy of Sciences of the United States of America
- Vu, Tri T. M.;Mitchell, Dylan C. et al. (2020) The Arg/N-degron pathway targets transcription factors and regulates specific genesProceedings of the National Academy of Sciences of the United States of America
- Vu, Tri T. M.;Varshavsky, Alexander (2020) The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron PathwayBiochemistry
- Dong, Cheng;Chen, Shun-Jia et al. (2020) Recognition of nonproline N-terminal residues by the Pro/N-degron pathwayProceedings of the National Academy of Sciences of the United States of America
- Oh, Jang-Hyun;Hyun, Ju-Yeon et al. (2020) Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchannelingProceedings of the National Academy of Sciences of the United States of America
- Chen, Shun-Jia;Melnykov, Artem et al. (2020) Evolution of Substrates and Components of the Pro/N-Degron PathwayBiochemistry