"Optical physics for biological imaging"
Abstract: Principles and techniques in physics and engineering have long enabled biological discovery. In particular, recent advances in optical microscopy have led to unprecedented gains in the depth, resolution, and speed at which biological specimens can be imaged. Nevertheless, challenges remain. Biological tissues distort images and scatter light, compromising resolution and limiting imaging depth. I will discuss how we employ physical principles and recent technological innovations to probe cellular dynamics at high spatiotemporal resolution in living specimens, and will show how these methods can be applied to understand the functioning of the brain at the cellular and sub-cellular level.